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Articles (93)

Research Article

Available Online: 11 Jul 2025

Structural And Molecular Changes of Isonicotinylhydrazine Anti-Tubercular Drug in Alcohol Environment: An Intuition from Theory

Volume 2

Journal: Molecular Modeling Connect
Research Article

Available Online: 10 Jul 2025

The Effect of Demineralized Autogenous Tooth Block Bone on Lateral Sinus Augmentation: A Retrospective Study

Volume 2

When placing implants in the posterior maxilla, sinus floor elevation is often required due to insufficient alveolar bone volume. During the sinus augmentation procedure, the Schneiderian membrane is elevated, and the newly created space is filled with bone graft materials. Among various graft materials, autogenous bones are considered the most biologically suitable. However, harvesting autogenous bone can cause donor site morbidity and postoperative discomfort. Block-type autogenous tooth bone graft material..

Journal: Biomaterials Connect
Systematic Review

Available Online: 10 Jul 2025

Black Soldier Fly Larva: A Resource Insect Larva Worth Promoting in Achieving Sustainable Development Goals - A Systematic Review

Volume 1

Journal: Sustainable Food Connect
Research Article

Available Online: 07 Jul 2025

Porous Structure and Characterization of Activated Carbons from the Grape Stalks

Volume 1

Journal: Sustainable Processes Connect
Research Article

Available Online: 01 Jul 2025

A Novel MLLM-based Approach for Autonomous Driving in Different Weather Conditions

Volume 2

Journal: Computing&AI Connect
Research Article

Available Online: 30 Jun 2025

AI Enabled Facial Emotion Recognition Using Low-Cost Thermal Cameras

Volume 2

While expensive hardware has historically dominated emotion recognition, our research explores the viability of cost-effective alternatives by utilising IoT-based low-resolution cameras with Vision Transformers (ViTs) and Convolutional Neural Networks (CNNs). In this work, we introduce a novel dataset specifically for thermal facial expression recognition and conduct a comprehensive performance analysis using ResNet, a standard ViT model developed by Google, and a modified ViT model tailored to be trained on smaller..

Journal: Computing&AI Connect
Research Article

Available Online: 23 Jun 2025

Exploring a Hybrid Deep Learning Framework to Automatically Discover Topic and Sentiment in COVID-19 Tweets

Volume 2

COVID-19 has created a major public health problem worldwide and other problems such as economic crisis, unemployment, mental distress, etc. The pandemic is deadly in the world and involves many people not only with infection but also with problems, stress, wonder, fear, resentment, and hatred. Twitter is a highly influential social media platform and a significant source of health-related information, news, opinion and public sentiment where information is shared by..

Journal: Computing&AI Connect
Editorial

Published: 16 Jun 2025

Preface

Volume 1

It is my honor as Editor-in-Chief to present the first volume of Cancer Immunology Connect, a new peer-reviewed journal focused on the rapidly advancing fields of cancer immunology and immunotherapy. The aim of this first volume and of subsequent publications is to improve our insight into the role of the immune system in the development and progression of cancer, and discover how immune systems can be manipulated to target and..

Journal: Cancer Immunology Connect
Review Article

Available Online: 16 Jun 2025

Vascularized Organoid-on-chip Platforms: Expanding the Bioengineering Frontiers with Microfluidics

Volume 2

Organoids-on-a-chip (OoC) technology is a pivotal advancement in biomedical research, engineered to meticulously replicate the intricate physiological functions of organs within controlled in vitro microenvironments. A critical component for elevating the biological fidelity and physiological relevance of these advanced platforms is the integration of a functional vascular system, vital for nutrient and oxygen delivery, waste removal, and intricate cell-cell communication. In this context, microfluidic technology has proven to be an..

Journal: Biomaterials Connect
Research Article

Published: 23 Jun 2025

Descriptive Analysis of Reported Adverse Events Associated with Metoclopramide Using FDA Adverse Event Reporting System Databases

Volume 1

Journal: Clinical Pharmacy Connect
Mini-Review

Available Online: 02 Jun 2025

Epigenetic Insights into Bladder Cancer: The Role of Urine DNA Methylation Assays: Mini Review

Volume 2

Bladder cancer remains a major global health challenge due to its high incidence, recurrence rates, and reliance on invasive diagnostic procedures. While conventional methods like cystoscopy and urine cytology are standard, they often fall short in sensitivity, especially for early-stage disease. Epigenetic alterations, particularly DNA methylation, are now recognized as critical in bladder cancer development and progression. Non-invasive urine-based DNA methylation assays have emerged as promising diagnostic and monitoring tools..

Journal: GenoMed Connect
Research Article

Available Online: 30 May 2025

Clinical Diversity and Outcomes of Progressive Familial Intrahepatic Cholestasis Diagnosed by Whole Genome Sequencing in Pakistani Children

Volume 2

Progressive familial intrahepatic cholestasis (PFIC) is a rare group of genetic disorders that typically present in infants and children, often progressing to end-stage liver disease. Using whole genome sequencing (WGS) for diagnosis, we aimed to assess phenotypic features and outcomes, in Pakistani children with different types of PFIC. The study included 116 pediatric participants with five PFIC types: PFIC1, ATP8B1 gene (n=19); PFIC2, ABCB11 (n=28); PFIC3, ABCB4 (n=52); PFIC4 TJP2..

Journal: GenoMed Connect
Review Article

Available Online: 26 May 2025

The Intratumor Microbiome: An Untapped Avenue for Translational Applications in Cancer Immunotherapeutics

Volume 2

Journal: Cancer Immunology Connect
Editorial

Published: 23 May 2025

Fatty Allies: How Short-Chain Fatty Acids Turn the Tumor Microenvironment Against Cancer

Volume 1

Journal: Cancer Immunology Connect
Research Article

Available Online: 22 May 2025

Dynamic Information Security Systems through Adaptive Architecture

Volume 2

The manufacturing industry is at the forefront of a digital transformation that promises significant enhancements in product and service quality. However, this technological shift also raises concerns about data security and information protection. In response to these challenges, a research study was conducted to investigate cybersecurity incidents in manufacturers and assess the effectiveness of the Zero-Trust Architecture (ZTA) as a solution. The primary objectives of this research were to: examine..

Journal: Communications & Networks Connect
Research Article

Available Online: 19 May 2025

Quantum-Safe Networks for 6G an Integrated Survey on PQC, QKD, and Satellite QKD with Future Perspectives

Volume 2

Quantum computing presents significant issues to the current cryptographic landscape, especially with the upcoming deployment of 6G networks. Traditional cryptographic algorithms, such as Rivest-Shamir-Adleman (RSA) and Elliptic Curve Cryptography (ECC), are vulnerable to quantum-based attacks, leading to the need for Post-Quantum Cryptography (PQC), Quantum Key Distribution (QKD), and Satellite-based QKD solutions. This paper offers a comprehensive review of these quantum-safe technologies, discussing their integration within the context of 6G networks...

Journal: Computing&AI Connect
Research Article

Available Online: 16 May 2025

The ‘human intelligence’ linguistic variable is a potential fuzzy computational model for the natural languish expression ‘human intelligence’

Volume 2

This paper presents a fuzzy, computational model for the natural languish word ‘human intelligence’. This is a mathematical model that takes into account various interpretations of the word “intelligent” and enables comparisons between them for a given IQ index. The model is a linguistic variable mathematical model, built especially for the word ‘human intelligence’ and is called the ‘human intelligence’ linguistic variable. The model is constructed systematically along the whole..

Journal: Computing&AI Connect
Research Article

Published: 27 Jun 2025

Characterizing the Reducing Properties of Biofuels in Activating Metal Catalysts of Refinery Processes

Volume 1

Journal: Sustainable Processes Connect
Review Article

Published: 26 May 2025

A Review on the Cell-Penetrating Peptides

Volume 1

The therapeutic potential of biomacromolecules in treating various diseases is undeniable; however, their application is significantly limited by the inherent barrier function of the cell membrane. Cell-penetrating peptides (CPPs), a class of small peptides comprising fewer than 30 amino acids, have garnered considerable attention due to their exceptional ability to traverse cell membranes. These peptides ease the intracellular delivery of various macromolecules, such as proteins, polypeptides, and nucleic acids, thereby..

Journal: Cell Therapy & Engineering Connect
Review Article

Published: 12 May 2025

Artificial Intelligence at the Crossroads of Engineering and Innovation

Volume 2

The field of Artificial Intelligence (AI) is progressively transforming various advanced engineering disciplines, including mechanical, civil, electrical, aerospace, environmental, and biomedical engineering, through improved design, manufacturing, maintenance, and optimization methodologies. Yet, the disjointed and specialized state of the art too frequently prevents the cross-disciplinary application of AI solutions due to disparate performance measures, which result in reduced knowledge transfer and exaggerated performance in segregated domains. This study overcomes these issues..

Journal: Computing&AI Connect
Research Article

Published: 07 May 2025

Exploring Artesunate and Dihydroartemisinin for Mechanism on MMP-3 and MMP-13 via Molecular Docking and Molecular Dynamics

Volume 1

The application of natural products has drawn increasing attention in recent times. Artesunate (ART) and Dihydroartemisinin (DHA), being natural products with anti-inflammatory and cartilage protective capabilities, have shown potential in osteoarthritis (OA) treatment. OA is a highly prevalent degenerative joint disease globally, leading to a diminished quality of life and is a major cause of disability. Matrix metalloproteinase 3 (MMP-3) and MMP-13 play crucial roles in OA progression. Although ART..

Journal: Molecular Modeling Connect
Mini-Review

Published: 07 Mar 2025

Azilsartan Kamedoxomil: Solubility Enhancement Techniques

Volume 2

Journal: Biomaterials Connect
Review Article

Published: 15 May 2025

Current Standing and Future Potential of 3D Bioprinting and Biomaterials

Volume 2

Biomaterials play a pivotal role in advancing tissue engineering, offering significant potential in 3D bioprinting and translational medicine. Their development has led to the creation of innovative solutions in medical devices, dental implants, and prosthetics, where they serve to restore function and enhance patient quality of life. The success of these biomaterials is primarily dependent on important characteristics that guarantee their safe integration with the body and promote tissue regeneration,..

Journal: Biomaterials Connect
Research Article

Published: 30 Jun 2025

Effect of Acyl Chain Variation and Cholesterol on Structural and Dynamic Properties of Lipid Bilayer Probed by Simulation

Volume 1

Lipid ordering plays a crucial role in maintaining the mechanical strength of the lipid bilayer, which is influential in controlling biological functions. This is associated with the well-known phenomena of “phase state behavior” of the bilayer. The significant factors that influence phase state behavior are stimuli such as cholesterol, physiological conditions like temperature and pH, and the structure of the lipid molecule itself, which can differ either in the head..

Journal: Molecular Modeling Connect
Research Article

Published: 15 May 2025

Preparation and Characterization of Biocompatible Hydrogels Based on a Chitosan-Polyacrylamide Copolymer

Volume 2

Journal: Biomaterials Connect
Research Article

Published: 15 Apr 2025

Association of Expression of Immune Checkpoints in Tumor-Infiltrating CD4+ T Lymphocytes with Disease-Free Survival in Colorectal Cancer Patients

Volume 1

Journal: Cancer Immunology Connect
Research Article

Published: 21 Apr 2025

Identification of Hub Genes and Molecular Mechanisms of Association of PCOS, Breast, and Ovarian Cancers Using an Integrated Bioinformatics Analysis

Volume 2

Background: Oxidative stress plays a crucial role in various aspects of cancer and other diseases. While reactive oxygen species (ROS) serve as key signal molecules in physiological processes for the normal functioning of the female reproductive system, they have also been implicated in pathological processes such as polycystic ovary syndrome (PCOS). Some studies have reported a significantly higher risk of endometrial cancer in women with PCOS. However, the association of..

Journal: GenoMed Connect
Research Article

Published: 20 Mar 2025

Food and Medicine Homology Substance in Cancer Treatment: Mechanism of Astragalus against Pancreatic Cancer

Volume 1

Journal: Molecular Modeling Connect
Research Article

Published: 21 Mar 2025

Characteristics of Tumor Infiltrating Lymphocytes in Patients with Benign and Malignant Sinonasal Neoplasms

Volume 1

Introduction. Tumor infiltrating lymphocytes are a major component of sinonasal neoplasms, actively populating tumor tissue, yet their role remains poorly understood. The aim is to characterize subsets and functional profiles of tumor infiltrating lymphocytes in patients with benign and malignant sinonasal tumors. Materials and methods. Tumor infiltrating lymphocytes were isolated from the biopsy material of 58 patients: 18 with sinonasal malignancies, 23 with inverted papilloma and 17 with polypous rhinosinusitis..

Journal: Cancer Immunology Connect
Editorial

Published: 07 Mar 2025

Clinical Pharmacy at the Crossroads: Advancing Care, Improving Outcomes

Volume 1

Clinical pharmacy has evolved from a field that focuses on the dispensing and distribution of medications to a modern, colossal field that is imperative to the patient-driven care [1,2]. Clinical pharmacists play a multifaceted and crucial role in patient care via integrating knowledge and skills into clinical practice, thereby contributing to improved health outcomes. Specifically, they design tailored pharmacotherapy that matches patients’ needs, with a focus on ensuring medication safety..

Journal: Clinical Pharmacy Connect
Review Article

Published: 21 Mar 2025

Upcycled Mesenchymal Stem Cells: Repurposing Biological Waste Towards Sustainable Regenerative Therapies

Volume 1

Journal: Cell Therapy & Engineering Connect
Research Article

Published: 20 Mar 2025

Unusual Arrangement of Catalytic Loops of the Alcohol Dehydrogenase Enzyme During the Adsorption Process on a Graphitic Carbon Surface

Volume 1

Molecular dynamics simulations (MDs) were conducted to investigate the alcohol dehydrogenase (ADH) enzyme and its cofactor, nicotinamide adenine dinucleotide (NAD), solvated in an aqueous system on a graphite-carbon surface. The study focuses on key structural aspects of ADH, particularly its conformational changes, including the rotation of the catalytic domain, the coenzyme binding domain, and the rearrangement of the active center required for catalytic activation. MDs were performed for 100 ns..

Journal: Molecular Modeling Connect
Review Article

Published: 04 Mar 2025

Security and Privacy in the IIoT: Threats, Possible Security Countermeasures, and Future Challenges

Volume 2

Journal: Computing&AI Connect
Review Article

Published: 19 Mar 2025

Soluble Biomarkers as Predictors of Response to Immunotherapy in Non-Small Cell Lung Cancer (NSCLC)-Insights from the Tumor Microenvironment Perspective

Volume 1

Lung cancer is the major cause of mortality worldwide with non-small cell lung cancer (NSCLC) contributing to 85% of the cases. FDA-approved immune checkpoint inhibitors (ICI), anti-PD-1, and anti-PD-L1 are widely used as a standard treatment. However, the response rate is limited and is observed in only 20–40% of the patients. Therefore, predictive and prognostic biomarkers are needed to help differentiate responders from non-responders, enabling a better understanding of disease..

Journal: Cancer Immunology Connect
Systematic Review

Published: 21 Mar 2025

Epidemiological Investigation and Assessment of HEVs in Shellfish Based on Meta-Analysis

Volume 1

Hepatitis E virus (HEV) is an acute zoonotic infectious disease that can cause hepatitis E and may even lead to death in severe cases. Porcine organisms are regarded as the natural hosts carrying hepatitis E virus, and it is also commonly found in other products. Meanwhile, shellfish are also one of the main hosts. The aim of this study was to estimate the global prevalence of hepatitis E virus in..

Journal: Sustainable Food Connect
Mini-Review

Published: 11 Feb 2025

CRISPR-Cas9 is Revolutionizing AML Treatment as a Novel Therapy

Volume 1

This review explores the progression of CRISPR-Cas9 genome editing technology in gene therapy for acute myeloid leukemia. Acute Myeloid Leukemia, a serious blood cancer, presents formidable treatment obstacles and a dismal prognosis. Effective treatments for acute myeloid leukemia rely on a clear understanding of its intricate genetic mechanisms, and CRISPR-Cas9 technology offers precision and adaptability for targeting the disease’s oncogenic drivers. The dual intron-targeting method of CRISPR-Cas9 is showcased in..

Journal: Cancer Immunology Connect
Review Article

Published: 21 Mar 2025

Traditional Strategies and Cutting-Edge Technologies Used for Animal Breeding: A Comprehensive Review

Volume 1

Food security continues to remain a critical challenge confronting humanity. Worldwide, the demand for food products is extensively increasing. Today, the research of generating transgenic organisms is one of the fastest-developing biotechnology fields, as it promises sustainability of agriculture and aquaculture. Many of the animals observed today, including top-quality agricultural breeds such as Holstein cows and Landrace swine, have undergone significant changes and are entirely distinct from their wild ancestors...

Journal: Sustainable Food Connect
Research Article

Published: 20 Mar 2025

Prediction of Cognitive Impairment Using a Deep Learning Autoencoder Algorithm from a Singapore Study

Volume 2

Dementia is a decline in cognitive function, typically diagnosed when the acquired impairment becomes severe enough to impact social or occupational functioning. Between no cognitive impairment (NCI) and dementia, there are many intermediate states. Predictive cognitive impairment can be useful for initiating treatment to prevent further brain damage. Several deep learning-based approaches have been proposed for the classification of Magnetic Resonance Imaging (MRI) to diagnose Alzheimer’s disease (AD) or dementia...

Journal: Computing&AI Connect
Mini-Review

Published: 28 Feb 2025

A Mini Review on Used Medical Yarns in the Braiding Production Methods for Biomaterial Applications

Volume 2

Biomaterials are advanced materials that can be implanted within the body, depending on the required design criteria, usually as a result of the production of polymeric-based, and medical yarns by the braiding method. Braiding method is widely used in the production of biomaterials due to its advantages, including a high elastic modulus, high tensile strength, and high dimensional stability properties. The high biological and mechanical properties required in biomaterials depend..

Journal: Biomaterials Connect
Research Article

Published: 10 Mar 2025

A Novel Approach towards Establishing Free Space Optical Inter Satellite Links beyond the Kármán Line

Volume 1

The rapid surge in the technological advancement of humanity calls for development of faster, reliable & effective communication methods between satellites orbiting in outer space. The infamous inter-satellite link technology, coupled with free space optical communication is a robust solution for the same. While establishing this for low earth orbit satellites, it is critical to ensure that the links established across the two satellites avoid the atmosphere, i.e., the links..

Journal: Communications & Networks Connect
Perspective

Published: 28 Feb 2025

Precision Medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-Based Therapies, Challenges and Perspectives

Volume 2

This manuscript examines advancements in antigen-specific immunosuppression, as well as the potential and challenges of applying gene-editing technologies to autoimmune diseases driven by autoantibodies (AAbs). Current approved treatments fail to reach long-lived plasma cells (LLPCs), which may continue secreting pathogenic AAbs after immunobiological courses in some autoimmune illnesses. New approaches, some tested in vitro and some already undergoing clinical trials, such as the chimeric autoantibody receptor (CAAR)-T cells, BiTEs, affinity..

Journal: GenoMed Connect
Review Article

Published: 28 Feb 2025

Advances in Microfluidic Bioprinting for Multi-Material Multi-Cellular Tissue Constructs

Volume 1

3D bioprinting enables fabrication of cell-laden bioinks into complex, biomimetic tissues. However, achieving the spatial and functional heterogeneity of native tissues still poses significant challenges. Microfluidics has emerged as a complementary technology, offering precise control over material flow, mixing, and deposition at the microscale. This review highlights the integration of microfluidics with 3D bioprinting, with a particular focus on the development of advanced “printhead-on-a-chip” systems that enable real-time material switching,..

Journal: Cell Therapy & Engineering Connect
Research Article

Published: 18 Mar 2025

Physical Layer Security in Lossy Untrusted Relay Networks with Finite Blocklength

Volume 1

In this paper, we examine the physical layer security (PLS) in lossy untrusted relay networks, focusing on finite blocklength transmissions. In such networks, ensuring secure communication is particularly challenging due to the presence of untrusted relay nodes and the inherent limitations of short-packet transmissions. We propose the reliable-and-secure probability (RSP) as a performance metric to evaluate the likelihood that the destination node successfully recovers the transmitted message while untrusted relays..

Journal: Communications & Networks Connect
Research Article

Published: 21 Jan 2025

Preparation and Characterization of Thermoplastic Grafted Chitosan Compositions with L-Lactide as Potential Material for 3D Printing

Volume 2

Journal: Biomaterials Connect
Editorial

Published: 15 Jan 2025

The Potential of Artificial Intelligence and Machine Learning in Pharmacovigilance: An Update

Volume 2

The integration of artificial intelligence (AI) and machine learning (ML) into pharmacovigilance (PV) marks a transformative step towards enhancing drug safety and patient outcomes. With their unparalleled ability to analyze vast and complex datasets, AI/ML technologies offer unprecedented opportunities to revolutionize adverse drug event (ADE) monitoring, signal detection, and causality assessment. This editorial explores the state-of-the-art applications, key challenges, and actionable strategies to unlock the full potential of AI in..

Journal: GenoMed Connect
Editorial

Published: 31 Dec 2024

Preface

Volume 1

Welcome to the inaugural volume of the Computing & AI Connect (CAIC) Journal, a peer-reviewed, open-access journal committed to fostering advancements and innovation in computing sciences and technologies, and artificial intelligence. CAIC is a platform that is dedicated to exploring the profound and transformative impacts of computing and artificial intelligence on the different aspects of life. In recent years, AI has become the focus of researchers from different fields, working to..

Journal: Computing&AI Connect
Review Article

Published: 08 Jan 2025

Chronic Myelomonocytic Leukemia Relapse After Transplant

Volume 1

Relapse of Chronic Myelomonocytic Leukemia after allogeneic hematopoietic stem cell transplantation remains a significant challenge, with relapse rates reaching up to 50%, contributing to poor survival outcomes. This paper explores the factors influencing relapse, including disease biology and persistence of residual disease. Current, post- transplant strategies, such as maintenance therapies and immunomodulatory treatments, are discussed for their potential to reduce the likelihood of relapse. It also highlights emerging therapies, such..

Journal: Cancer Immunology Connect
Review Article

Published: 20 Dec 2024

Nanotechnology Based Drug Delivery Systems of Herbal Medicine

Volume 2

Journal: Biomaterials Connect
Systematic Review

Published: 07 Feb 2025

A Systematic Review on the Integrating Artificial Intelligence for Enhanced Fault Detection in Power Transmission Systems: A Smart Grid Approach

Volume 2

Modern electrical systems rely on sensors and relays for fault detection in three-phase transmission lines and distribution transformers, but these devices often face time complexity issues and false alarms. In this study, the fault detection accuracy is compared in models studied in 2023 and 2024 following PRISMA guidelines. The objectives were to identify fault types, utilize machine learning models to assess their predictive efficacy, and establish accuracy levels. To explore..

Journal: Computing&AI Connect
Editorial

Published: 28 Nov 2024

Preface

Volume 1

It is both an honor and a privilege to introduce this inaugural issue of Biomaterials Connect. Biomaterials Connect is a newly established journal that intends to be an inclusive forum for all researchers, scientists, engineers, and professionals working within the various fields of biomaterials science. The purpose is to encourage the contribution to multi-disciplinary interaction, the diffusion of new ideas, and contributing to biomaterials research and applications, but in particular..

Journal: Biomaterials Connect
Case Report

Published: 29 Nov 2024

Epidermolytic Hyperkeratosis Type 1 with a New Heterozygous Mutation in KRT1 Gene: A Case Report

Volume 1

Background: Epidermolytic hyperkeratosis (EHK) formerly known as bullous ichthyosiform erythroderma, is a rare autosomal dominant inheritance condition with a prevalence ranging from 1:200,000 to 1:300,000. The underlying etiology of which is a mutation in the genes responsible for keratin proteins synthesis, primarily in KRT1 and KRT10 genes, cataloged under OMIM number 113800. The clinicopathological presentations include blistering during the neonatal period, followed by ichthyotic hyperkeratosis in childhood and adolescence. This..

Journal: GenoMed Connect
Research Article

Published: 20 Nov 2024

Impact of Surface Modification of Hemp Fibers Using a Coupling Agent in Solvent on the Properties of Polyethylene Composites

Volume 1

This study investigates the grafting of a coupling agent, maleic anhydride-grafted polyethylene (MAPE), onto hemp fibers in a 1,2,4-trichlorobenzene (TCB) solution, followed by an evaluation of the morphological, rheological, and mechanical properties of the resulting polyethylene composites containing 30% hemp. SEM analysis revealed the formation of a thin layer of MAPE on the surface of the modified fibers. This was further confirmed by the appearance of a MAPE degradation peak..

Journal: Biomaterials Connect
Review Article

Published: 18 Nov 2024

Biofunctional Applications of Chitosan in Dentistry - An Overview

Volume 1

Chitosan, with its unique properties, has garnered the interest of materials scientists worldwide, leading to exploration in bio-dental applications. In dentistry, chitosan has shown a wide range of applications. The creation of effective biomaterials for the prevention and treatment of dental disorders is a challenge for researchers in the present scenario. The natural semi-synthetic polysaccharide-based biomaterial Chitosan is derived from chitin, which is sourced from marine organisms. Due to its..

Journal: Biomaterials Connect
Letter

Published: 05 Nov 2024

Arsenic, Mercury, Lead and Iron Induced Lipid Peroxidation in Phospholipids Liposomes and Protective Effect of Fumaric Acid

Volume 1

Journal: Sustainable Food Connect
Research Article

Published: 24 Oct 2024

Preparation and Characterization of Acetate Cellulose Laurate Ester in Sodium Acetate/Zinc Chloride Systems

Volume 1

The objective of this study was to explore the preparation and characterization of acetate cellulose laurate ester in sodium acetate/zinc chloride systems. The cellulose used in the study was obtained from oil palm empty fruit bunch and oil palm frond. The characterization of both the isolated cellulose and the acetate cellulose laurate ester was carried out using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Differential thermogravimetric (DTG), and Thermogravimetric..

Journal: Biomaterials Connect
Review Article

Published: 21 Oct 2024

Neoantigen-Based Cancer Vaccines: Current Innovations, Challenges and Future Directions in Personalized Immunotherapy

Volume 1

Journal: Cancer Immunology Connect
Editorial

Published: 11 Oct 2024

Exploring a New Era in Cell Engineering

Volume 1

As the Editor-in-Chief of Cell Engineering Connect, it is both an honor and a privilege to introduce this inaugural issue. Our journal is dedicated to exploring the latest advancements in the rapidly evolving field of cell engineering, an interdisciplinary domain that holds the key to transformative innovations in healthcare, biotechnology, and synthetic biology. The convergence of cell biology, bioengineering, and data science is enabling researchers to manipulate cellular systems in..

Journal: Cell Therapy & Engineering Connect
Research Article

Published: 17 Oct 2024

Investigation of TLR4, TLR6, TLR7, and CD36 Expression on T lymphocytes in Coronary Artery Disease

Volume 1

Background: Coronary artery disease (CAD) is among the significant causes of death globally, caused by fatty deposits in blood vessel walls. Increasing evidence indicates that toll-like receptors (TLRs) are pivotal to atherosclerosis progression. The function of CD36 as a glycoprotein in atherosclerosis was also suggested. This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD. Methods: This study included..

Journal: GenoMed Connect
Editorial

Published: 10 Sep 2024

3D Printing of Biomaterials: Is It Disruptive or Destructive?

Volume 1

3D printing represents a new era in the field of digital manufacturing, finding its applications in many industries, such as healthcare, automotive, and aerospace. In particular, 3D printing has the potential to completely revolutionize the manufacturing process for implants, medical equipment, and even human tissues within the healthcare industry. The rapid rise of 3D printing raises fundamental questions i.e., Is this technology truly revolutionary, or does it perhaps take us..

Journal: Biomaterials Connect
Research Article

Published: 10 Sep 2024

Diversity of HLA Class I and II Genes in the North Indian Population

Volume 1

Introduction: Numerous studies have concentrated on specific populations to explore the extensive polymorphism of class I and II HLA genes. This genetic diversity is crucial for various applications, such as advancing transplantation immunology, understanding genetic population patterns, and uncovering the pathways of different diseases. Objective: The objective of the present study was to determine and analyse the frequencies of class I (HLA-A, HLA-B and, HLA-C), and class II (HLA-DRB1, and..

Journal: GenoMed Connect
Review Article

Published: 29 Aug 2024

Ethical Approaches in Secondary Findings Report from Exome Sequencing Analysis

Volume 1

In Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) approaches, incidental findings (IFs) or more precisely secondary findings (SFs) have indicated controversial reports. To address SFs issues, well-known guidelines have been released such as the versions of the American College of Medical Genetics and Genomics (ACMG); however, when, to whom, why, and how these SFs should be reported are the key questions that need to be addressed ethically. The..

Journal: GenoMed Connect
Review Article

Published: 23 Aug 2024

The Secret Life of Microbes: The Expanding Role of Microbes in Shaping Endocrine Health—The Role of Microbes in Endocrinology Health

Volume 1

This review was intended to attempt to establish the complex association between the endocrine system of the host and the gut microbiota. Microbial endocrinology is a relatively new field of study, which examines how microbes regulate hormonal; and affect metabolisms, immune system, and behavior responses. This is because the gut microbiome can be viewed as a virtual endocrine organ as it is involved in the synthesis of neuroactive substances as..

Journal: GenoMed Connect
Review Article

Published: 28 Aug 2024

An Overview of Secure Network Segmentation in Connected IIoT Environments

Volume 1

Network segmentation is a very important approach in enhancing network security. The approach involves breaking down the network into smaller, more manageable segments, each with its own specific security requirements. This strategy supports maintaining stable perimeters and effective access control while safeguarding critical resources, such as database servers, from unauthorized access. The relevance of network segmentation in IIoT comes with the state-of-the-art and interconnected nature of many devices that may..

Journal: Computing&AI Connect
Research Article

Published: 02 Aug 2024

Challenging Conventions Towards Reliable Robot Navigation Using Deep Reinforcement Learning

Volume 1

Effective indoor navigation in the presence of dynamic obstacles is crucial for mobile robots. Previous research on deep reinforcement learning (DRL) for robot navigation has primarily focused on expanding neural network (NN) architectures and optimizing hardware setups. However, the impact of other critical factors, such as backward motion enablement, frame stacking buffer size, and the design of the behavioral reward function, on DRL-based navigation remains relatively unexplored. To address this..

Journal: Computing&AI Connect
Research Article

Published: 29 Jul 2024

Mirror, Mirror on the Wall: Automating Dental Smile Analysis with AI in Smart Mirrors

Volume 1

This paper presents a smart diagnostic framework for dental smile analysis. To accurately and efficiently identify esthetic issues from a single image of a smile, a convolutional neural network (CNN) was trained. To overcome the limitations of scarce data, a diffusion model was employed to generate dental smile images in addition to manually curated data. The CNN was trained and evaluated on three datasets: all real images, all generated images,..

Journal: Computing&AI Connect
Research Article

Published: 29 Jul 2024

Translucency and Polymerization Ability of Contemporary Resin Composites

Volume 1

Objective: The present study aimed to characterize the translucency and polymerization ability of commercially available contemporary resin composites. Methods: The resin composites considered in this study were Forma (Enamel, Body, and Dentin; Ultradent), Empress Direct (Enamel and Dentin; Ivoclar/Vivadent), Sirius-Z (Enamel and Dentin; DFL), and Orion (Enamel and Dentin; DFL). All photoactivation procedures were performed using the same light source (Valo Cordless, Ultradent, 20 s). The translucency parameter (TP) was..

Journal: Biomaterials Connect
Review Article

Published: 13 Jun 2024

Hierarchical Autoencoder-Based Lossy Compression for Large-Scale High-Resolution Scientific Data

Volume 1

Lossy compression has become an essential technique to reduce data size in many domains. This type of compression is especially valuable for large-scale scientific data, whose size ranges up to several petabytes. Although Autoencoder-based models have been successfully leveraged to compress images and videos, such neural networks have not widely gained attention in the scientific data domain. Our work presents a neural network that not only significantly compresses large-scale scientific..

Journal: Computing&AI Connect
Editorial

Published: 11 Jul 2025

Preface

Volume 1

Welcome to the inaugural volume of MolMod Connect—a dynamic, peer-reviewed, open-access journal dedicated to advancing the frontiers of molecular modeling and simulation. Published biannually in print and online, MolMod Connect offers an inclusive and thoughtfully curated platform for high-quality research that pushes the boundaries of knowledge and innovation in this rapidly evolving field. Molecular modeling has sparked what can be described as a predictive revolution in science, enabling researchers worldwide..

Journal: Molecular Modeling Connect
Editorial

Published: 07 Jul 2025

The Predictive Revolution: Rethinking Science Through Molecular Modeling

Volume 1

Journal: Molecular Modeling Connect
Research Article

Published: 27 Jun 2025

The Impact of Toxic Effector Molecule TagX on the Amino Acid Conformation of the Hcp1 Monohexameric Ring in Acinetobacter baumannii Type VI Secretion System Utilizing Bioinformatics Tools and an AI System

Volume 2

Limited information is currently available regarding the contraction mechanism of the Hcp-1 hemolysin-coregulated protein within the type VI secretion system (T6SS) of Acinetobacter baumannii, particularly about the secretion of toxic effectors. This research aimed to evaluate the mechanism underlying the contraction of the Hcp1 nanotube in response to the putative toxic effector TagX protein by employing bioinformatics tools and the artificial intelligence (AI) DeepMind system. To achieve this goal, the..

Journal: Molecular Modeling Connect
Review Article

Published: 25 Jun 2025

Advanced Subtractive Manufacturing, Micromilling, and Laser Micromachinery in Dentistry: Current Applications, Limitations, and Future Perspectives

Volume 2

Objectives: To comprehensively overview the computer-aided design/computer-aided manufacturing (CAD/CAM) technology, focusing primarily on subtractive manufacturing or Computer Numerical Control (CNC) milling, with special attention to advancements and future requirements. Materials and Methods: A comprehensive web search was conducted in April 2024 across PubMed, Scopus, and Web of Science databases. The inclusion criteria focused on English peer-reviewed studies addressing technological advancements, grinding modes, and limitations. However, non-English articles, case reports, opinion..

Journal: Biomaterials Connect
Research Article

Published: 25 Jun 2025

Political Instability and the Treadmill of Production: Sustainable Urban Processes in Kabul City

Volume 1

Political instability and weak institutional governance have exacerbated environmental degradation in Kabul City, where the relentless treadmill of production continues to strain natural resources. This study examines how weak institutional governance, conflict, corruption, and economic pressures contribute to unsustainable environmental practices, intensifying pollution, deforestation, and resource depletion. As political instability weakens institutional capacities, regulatory enforcement diminishes, allowing industrial and urban expansion to proceed unchecked. The treadmill of production, driven by..

Journal: Sustainable Processes Connect
Research Article

Published: 23 Jun 2025

Sustainable Processes and Planned Obsolescence in the Textile and Clothing Sector in Portugal

Volume 1

Journal: Sustainable Processes Connect
Research Article

Published: 07 May 2025

A Novel Transformer Reinforcement Learning-Based NFV Service Placement in MEC Networks

Volume 2

The advent of 5G networks has facilitated various Industry 4.0 applications requiring stringent Quality-of-Service (QoS) demands, notably Ultra-Reliable Low-Latency Communication (URLLC). Multi-Access Edge Computing (MEC) has emerged as a key technology to support these URLLC applications by bringing computational resources closer to the user, thus reducing latency. Meanwhile, Network Function Virtualization (NFV) supports 5G networks by offering flexibility and scalability in service provisioning across various applications. Despite their benefits, MEC..

Journal: Computing&AI Connect
Research Article

Published: 06 May 2025

Comprehensive Classification of Web Tracking Systems: Technological Insights and Analysis

Volume 2

Web tracking (WT) systems are advanced technologies that are used to monitor and analyze online user behavior. Initially focused on HTML and static webpages, these systems have evolved with the proliferation of IoT, edge computing, and Big Data, encompassing a broad array of interconnected devices with APIs, interfaces, and computing nodes for interaction. WT systems are pivotal in technological innovation and business development, although trends like GDPR complicate data extraction..

Journal: Computing&AI Connect
Review Article

Published: 28 Apr 2025

Synergistic Modulation of ER Stress and Insulin Potentiation Therapy for Enhanced Cancer Treatment

Volume 1

Cancer cells sustain rapid growth by reprogramming their metabolism to depend heavily on glycolysis, enhanced insulin signaling, and adaptive changes in the unfolded protein response (UPR). Insulin Potentiation Therapy (IPT) enhances the efficacy of chemotherapy by increasing insulin receptor expression, thereby improving the uptake of chemotherapeutic agents. Meanwhile, targeting endoplasmic reticulum (ER) stress disrupts the protein-folding machinery within cancer cells, steering them toward apoptosis. However, IPT faces several limitations, including..

Journal: Cell Therapy & Engineering Connect
Research Article

Published: 04 Apr 2025

Smart Gas Sensing by (Al/C/Si)-Doped Boron Nitride Nanomaterial Towards Grabbing Nitric Oxide: A Novel Applied Technique for Air Pollution Reduction by DFT Analysis

Volume 1

The electronic, magnetic, and thermodynamic properties of adsorption of toxic gases, including Nitric oxide (NO) by using Y (Y = Al, C, Si)-doped boron nitride nanocage (BN) have been investigated using density functional theory (DFT). The results denote that NO→Y–BN are stable compounds, with the most stable adsorption site being the center of the cage ring. Furthermore, the reported results of nuclear magnetic resonance (NMR) spectroscopy have exhibited the strength..

Journal: Molecular Modeling Connect
Editorial

Published: 28 Mar 2025

Preface

Volume 1

Welcome to the inaugural volume of Comm&Optics Connect, a multidisciplinary journal dedicated to advancing communication and networks across the entire electromagnetic spectrum. This first volume embodies our vision to provide a platform where groundbreaking research in radio, mmWave, THz, and optical technologies converges. The future of communication networks lies in the seamless integration of technologies across the electromagnetic spectrum to support ultra-high speed, ultra-low latency, and massive connectivity. However, realizing..

Journal: Communications & Networks Connect
Research Article

Published: 09 Jan 2025

How Caffeine Affects Alpha-Amylase: An In Vivo Study

Volume 2

Background: Caffeine is a widely consumed psychostimulant with various effects, including weight and metabolic parameters. Caffeine consumption has been associated with increased blood glucose levels and reduced insulin sensitivity. Since xanthine derivatives like caffeine can activate alpha-amylase, an enzyme essential for carbohydrate-to-glucose conversion, this study investigates whether this translates to increased amylase activity in living organisms and explores potential gene expression changes. Methods: Male NMRI mice were divided to 5..

Journal: GenoMed Connect
Review Article

Published: 31 Dec 2024

Distributed Reinforcement Learning for IoT Security in Heterogeneous and Distributed Networks

Volume 1

The explosive growth of the Internet of Things (IoT) has significantly increased networked devices within distributed and heterogeneous networks. Due to these networks’ inherent vulnerabilities and diversity, the proliferation of IoT devices presents substantial security challenges. Traditional security solutions face challenges in keeping up with the constantly changing threats in dynamic situations. This article reviews the application of distributed Reinforcement Learning approaches to enhance IoT security in dispersed and heterogeneous..

Journal: Computing&AI Connect
Research Article

Published: 26 Dec 2024

Study of the 3-(3,3-Dimethylbutanoyl)-4-hydroxy-6-neopentyl-2H-pyran-2-one by IR, Raman spectroscopy, and DFT

Volume 1

Journal: Molecular Modeling Connect
Research Article

Published: 12 Dec 2024

The Placement of Auer Rods as a Single Diagnostic Criterion for the Highest-Risk Category of Myelodysplastic Syndromes: A Single-Institution Study and Critical Analysis

Volume 2

Accurate determination of prognostic risk is critical for patients and treating clinicians. The French-American-British classification of myelodysplastic syndromes (MDS) described refractory anemia with excess blasts (RAEB) in transformation (RAEB-T), including two subsets with <20% bone marrow (BM) blasts, which were reclassified as RAEB-2, the highest-risk MDS category in the 2001 World Health Organization classification. Those diagnostic criteria have been retained until now with nomenclature changes from RAEB-2 to “MDS with..

Journal: GenoMed Connect
Editorial

Published: 30 Nov 2024

Preface

Volume 1

As Editor-in-Chief of GenoMed Connect, it is my great pleasure to introduce the inaugural issue of this journal, dedicated to bridging the fields of genomics and medicine. Our vision for GenoMed Connect is to serve as a platform for the latest research that informs precision medicine and promotes integrative healthcare approaches. This inaugural issue features a diverse collection of seven articles, showcasing the journal's commitment to interdisciplinary research and its..

Journal: GenoMed Connect
Research Article

Published: 19 Nov 2024

Technological Trends in Open Fronthauls for Beyond 5G and 6G Networks

Volume 1

Ultra-massive interconnection composed of extremely small to minuscule networks that are significantly overloaded is required for the fifth generation (5G) and the next sixth generation (6G) networks. In order to meet the demands for network flexibility, complete coverage, and huge access, the conventional radio access network (RAN) will be completely revamped. This study focuses on the technological trends in the requirements-fulfilling Open RAN (ORAN) architecture and essential technologies in this..

Journal: Communications & Networks Connect
Research Article

Published: 15 Nov 2024

Social Media and Artificial Intelligence for Sustainable Cities and Societies: A Water Quality Analysis Use-Case

Volume 1

Crowd-sourcing has been widely explored for monitoring and feedback on infrastructure and services, such as air and water quality analysis. However, the traditional methods of crowd-sourcing for feedback and analysis of water quality, such as offline and online surveys, have several limitations, such as the limited number of participants and low frequency due to the labor involved in conducting such surveys. Social media analytics could overcome these challenges by providing..

Journal: Computing&AI Connect
Research Article

Published: 14 Nov 2024

Metal Ions Released During Canine Retraction Using Fixed Orthodontic Appliance: Prospective Clinical Study

Volume 1

Background: Metal ions released from dental alloys pose a significant concern due to their potential local and systemic effects. One of these effects is hypersensitivity, particularly associated with nickel-containing dental alloys. Aims: to measure metal ion concentration in saliva during orthodontic space closure on a 0.019X0.025 working archwire. Material and Methods: Trial design: Controlled clinical trial. Setting: Orthodontic treatment was provided at the Postgraduate Orthodontic Teaching Clinics and saliva testing was..

Journal: Biomaterials Connect
Research Article

Published: 05 Nov 2024

Evaluation of IL 12 Gene Expression and Serum Levels of OxPL / apoB in Patients with Coronary Artery Disease

Volume 1

Background Atherosclerotic lesions are formed as a result of low-density lipoprotein (LDL) accumulation, which is produced by oxidizing enzymes and oxidized phospholipids (OxPL). Phospholipid oxide causes inflammation-inducing activation genes and hyper-inflammation in addition to the initiation of inflammation and expression of Th1 cytokines. Interleukin 12 (IL-12) is one of the most significant stimulants of inflammation and immune responses, among the Th1cytokines. Therefore, it may play a significant role in contributing..

Journal: GenoMed Connect
Research Article

Published: 27 Oct 2024

Refining the Scrum Paradigm: A Comprehensive Research of Software Development Practices (2020–2023)

Volume 1

This article presents a complex vision on software production practices aimed at enhancing the Scrum methodology within software project management. The recommended best practices are closely aligned with contemporary trends in the IT sector, including the total digitalization and virtualization of production processes, the transition to fully remote software development models, the incorporation of artificial intelligence technologies, and the implementation of cost-effective models in team organization. The modifications to software..

Journal: Computing&AI Connect
Review Article

Published: 25 Oct 2024

Review on Next-Gen Healthcare: The Role of MEMS and Nanomaterials in Enhancing Diagnostic and Therapeutic Outcomes

Volume 1

The convergence of microelectromechanical systems (MEMS) and nanomaterials is transforming healthcare by enabling diagnostics, drug delivery, and biosensing breakthroughs. This synergistic integration offers unprecedented precision, miniaturization, and biocompatibility, overcoming critical challenges in detecting disease markers and delivering therapies. When combined with nanomaterials, MEMS-based devices achieve heightened sensitivity and specificity, allowing for early diagnosis and targeted treatments across various medical applications. This fusion holds immense potential in advancing personalized medicine, from..

Journal: Biomaterials Connect
Research Article

Published: 28 Sep 2024

Towards Low Complexity VLC Systems: A Multi-Task Learning Approach

Volume 1

In the rapidly evolving landscape of wireless communication, visible light communication (VLC) stands out for its potential to redefine high-speed data exchange. Recently, VLC has utilized waveforms that combine multiple bitstreams in a unified physical layer, allowing for high-speed data exchange, precise localization, and robust control simultaneously. Particularly, the demodulation tasks of beacon position modulation (BPM) and beacon phase shift keying (BePSK) are central to decoding of such waveforms and..

Journal: Communications & Networks Connect
Research Article

Published: 26 Sep 2024

In Silico Investigation of the Constituents of Aroeira Honey (Astronium urundeuva) and the Binding Affinity with Important Proteins of M. leprae and M. tuberculosis

Volume 1

Journal: Molecular Modeling Connect
Research Article

Published: 23 Sep 2024

Identification of Prognostic Biomarkers and Tumor Immune Microenvironment about Uveal Melanoma

Volume 1

Uveal melanoma (UM) is a malignant eye cancer that has a high mortality rate and is notoriously difficult to diagnose clinically. Identifying prognostic biomarkers and evaluating the tumor immune microenvironment for UM in order to improve diagnosis, treatment decisions and even overall survival for patients. The study involved a comprehensive analysis of transcriptome profiling from the TCGA-UVM project, with the aim of identifying biomarkers and exploring the relationship between the..

Journal: GenoMed Connect
Research Article

Published: 10 Sep 2024

A Cloud Based IoT Electricity Consumption Monitoring Platform for a Residential Household

Volume 1

Energy costs are a concern, given the rate of increase in energy costs. The unprecedented switch to electricity as a source of energy is reflected in the growth of the electric vehicle, solar panel and heat pump markets as consumers compete with reducing fossil energy consumption. This paper evaluates electricity usage in two households, namely Household A and Household B using energy kilowatt hour, power wattage and the outside weather..

Journal: Communications & Networks Connect
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