Available Online: 30 Dec 2025

Spatial Omics in Decoding Oral Squamous Cell Carcinoma Heterogeneity: Microenvironment Crosstalk and Multi-Omics Integration

Volume 2

Oral squamous cell carcinoma (OSCC) is a major issue in the sphere of head and neck cancer since it is very heterogeneous, which also leads to the poor treatment results and low survival rates in the advanced stages. Here, the review will discuss how spatial omics methods explore tumor heterogeneity in OSCC, which includes cellular, molecular, and immune microenvironment alterations that occur due to cancer stem cells, stromal interactions, genetic..

Available Online: 30 Dec 2025

Advancing Sustainable Food Systems Through Science, Innovation and Collaboration

Volume 1

Available Online: 23 Dec 2025

Covalent BH3-Mimetics and PROTACs Targeting BCL2 Family for Precision Apoptosis Induction

Volume 1

The BCL2 family of proteins serves as a central regulator of mitochondrial outer membrane permeabilization (MOMP) and intrinsic apoptosis, with anti-apoptotic members such as BCL2, BCL-XL, and MCL1 frequently overexpressed in cancers to evade programmed cell death. Traditional BH3 mimetics, like venetoclax and navitoclax, have revolutionized treatment for hematologic malignancies by competitively inhibiting these pro-survival proteins, yet they face challenges including acquired resistance, on-target toxicities and limited efficacy in solid..

Available Online: 09 Dec 2025

Data Delivery for Standardizing Sustainable Whole-building Lifecycle Assessment Using the Proposed OpenBIM Framework

Volume 1

Whole-Building Lifecycle Assessment (wbLCA) is an essential tool for evaluating the environmental impacts of buildings, including the benefits of material reuse. wbLCA can help the Architecture, Engineering, Construction, and Operation (AECO) industry reduce greenhouse gas (GHG) emissions. However, the effectiveness of wbLCA is contingent upon the availability, the quality, and the exchange of data, leading to significant inconsistencies in LCA assessments and analyses. To address the issue of consistency and..

Published: 08 Dec 2025

Emerging Nanotechnologies in Pharmaceutical Sciences: Opportunities and Challenges

Volume 1

It is my honor to serve as the Editor-in-Chief of Pharmaceuticals and Nanotech Connect, a newly established journal by Scifiniti, and to introduce its inaugural issue. Our journal provides a dynamic platform that bridges recent advancements in nanotechnology and conventional pharmaceutical sciences, fostering innovation and translational research while promoting the global integration of education, research, and practice in pharmacy and nanotechnology. The focus of this journal is to disseminate creative..

Available Online: 03 Dec 2025

Editorial

Volume 1

It is my pleasure to present this first issue of Ecological and Sustainable Materials Connect. This new journal aims to provide a platform for researchers, scientists, engineers, and practitioners across various fields who are committed to developing sustainable solutions and improving design options to create better sustainable societies and produce efficient, eco-friendly bio-products in the future. We intend to encourage multidisciplinary cooperation, facilitate the exchange of new ideas, and promote..

Published: 25 Nov 2025

6G Communication Systems Utilizing Intelligent Reflective Surfaces for Improved Data Rates Based on AI

Volume 2

Intelligent Reflecting Surfaces (IRSs) are essential for energy-efficient 6G networks; however, enhancing their performance to attain both elevated data rates and energy efficiency continues to be a formidable challenge. This paper uses artificial intelligence (AI) to solve this problem by creating a new AI-based optimization algorithm called Dynamic and Static Particle Swarm Optimization (DS-PSO). The suggested AI method intelligently learns the best phase-shift settings for IRS elements, balancing exploration and..

Published: 31 Oct 2025

Exploring Neuromarketing Techniques for Advancing Sustainability in India’s Food and Agribusiness Sector

Volume 1

Despite growing global interest, neuromarketing remains underutilized within India’s agri-food sector. This study examines the awareness, application, and potential of neuromarketing tools, including EEG (electroencephalography), eye-tracking, the Implicit Association Test (IAT), and virtual or augmented reality (VR/AR), in influencing sustainable consumer behavior in India. Respondents were selected using purposive and snowball sampling techniques, ensuring a diverse representation of stakeholders. While global corporations leverage neuroscience to refine marketing strategies, Indian agribusinesses..

Published: 21 Oct 2025

Prevalence of Helicobacter pylori Infection in India: A Systematic Review and Meta-Analysis

Volume 1

This study estimated the prevalence of H. pylori infection in India among adults and children with and without gastrointestinal (GI) disorders. This meta-analysis was conducted in accordance with the 2020 PRISMA guidelines and registered with PROSPERO (CRD42024597401). Scientific databases (e.g., MEDLINE, CINAHL, and Google Scholar) were searched to identify English-language articles from India presenting data on H. pylori prevalence. The quality of the included studies was assessed, and prevalence estimates..

Published: 03 Oct 2025

Current Insights into Pharmacogenomics of Noncoding RNAs for Cancer Therapy

Volume 2

Cancer remains a significant global health challenge, with varying incidence and mortality rates across the globe. According to the Surveillance, Epidemiology, and End Results (SEER) registry [1] and the American Cancer Society (ACS) [2], more than 2 million new cancer cases are expected in the US by 2025. Understanding the burden of disease and advancements in tailored treatments, also known as precision or personalized medicine, is crucial for improving patient..

Published: 28 Sep 2025

The Role of Pharmacists in Public Health and Disease Prevention: What Do We Know?

Volume 1

Background: Non-communicable diseases and persistent infectious threats continue to cause substantial premature mortality. Over 85% of the global population lives within walking distance of a pharmacy, positioning pharmacists as highly accessible primary-health providers. Aims: To review evidence on pharmacists’ public-health activities, propose a four-domain service framework, and identify barriers limiting scale-up, particularly in low- and middle-income settings. Methods: A conventional narrative review was conducted. Targeted manual searches of PubMed, Scopus,..

Published: 16 Sep 2025

Revolutionizing Cardio-Oncology: Utilizing Artificial Intelligence to Build a Cutting-Edge Cancer Registry in Pakistan

Volume 2

Cardio-oncology is a specialized field focused on delivering effective cancer therapies while minimizing cardiotoxicity. It also involves strategies for the timely identification and appropriate management of cardiovascular complications arising from cancer treatment. Cancer patients have the highest mortality from cardiovascular disease, underscoring the critical importance of the field of cardio-oncology. Currently, data on the outcomes of specialized cardio-oncology services are limited, highlighting a pressing need to establish a comprehensive and..

Published: 21 Jul 2025

AI Enabled Facial Emotion Recognition Using Low-Cost Thermal Cameras

Volume 2

While expensive hardware has historically dominated emotion recognition, our research explores the viability of cost-effective alternatives by utilising IoT-based low-resolution cameras with Vision Transformers (ViTs) and Convolutional Neural Networks (CNNs). In this work, we introduce a novel dataset specifically for thermal facial expression recognition and conduct a comprehensive performance analysis using ResNet, a standard ViT model developed by Google, and a modified ViT model tailored to be trained on smaller..

Published: 14 Jul 2025

Exploring a Hybrid Deep Learning Framework to Automatically Discover Topic and Sentiment in COVID-19 Tweets

Volume 2

COVID-19 has created a major public health problem worldwide and other issues such as economic crisis, unemployment, mental distress, etc. The pandemic has affected people not only through infection but also by causing stress, worry, fear, resentment, and even hatred. Twitter is a highly influential social media platform and a major source of health-related information, news, opinions, and public sentiment, with content shared by both individuals and official government sources...

Published: 27 Jun 2025

Vascularized Organoid-on-Chip Platforms: Expanding the Bioengineering Frontiers with Microfluidics

Volume 2

Organoids-on-a-chip (OoC) technology is a pivotal advancement in biomedical research, engineered to meticulously replicate the intricate physiological functions of organs within controlled in vitro microenvironments. A critical component for elevating the biological fidelity and physiological relevance of these advanced platforms is the integration of a functional vascular system, vital for delivering nutrients and oxygen, waste removal, and intricate cell-cell communication. In this context, microfluidic technology has proven to be a..

Published: 24 Jun 2025

Epigenetic Insights into Bladder Cancer: The Role of Urine DNA Methylation Assays: Mini Review

Volume 2

Bladder cancer remains a major global health challenge due to its high incidence, recurrence rates, and reliance on invasive diagnostic procedures. While conventional methods, such as cystoscopy and urine cytology, are considered standard, they often demonstrate limited sensitivity, particularly in detecting early-stage disease. Epigenetic alterations, particularly DNA methylation, are now recognized as critical in bladder cancer development and progression. Non-invasive urine-based DNA methylation assays have emerged as promising diagnostic and..

Published: 23 Jun 2025

Clinical Diversity and Outcomes of Progressive Familial Intrahepatic Cholestasis Diagnosed by Whole Genome Sequencing in Pakistani Children

Volume 2

Progressive familial intrahepatic cholestasis (PFIC) is a rare group of genetic disorders that typically presents in infants and children, often progressing to end-stage liver disease. We used whole genome sequencing (WGS) for diagnosis to assess phenotypic features and outcomes in Pakistani children with different types of PFIC. The study included 116 pediatric participants with five PFIC types: PFIC1, ATP8B1 gene (n = 19); PFIC2, ABCB11 (n = 28); PFIC3, ABCB4..

Published: 26 Jun 2025

Dynamic Information Security Systems through Adaptive Architecture

Volume 2

The manufacturing industry is at the forefront of a digital transformation that promises significant enhancements in product and service quality. However, this technological shift also raises concerns about data security and information protection. In response to these challenges, a research study was conducted to investigate cybersecurity incidents in the manufacturers and assess the effectiveness of the Zero-Trust Architecture (ZTA) as a solution. The primary objectives of this research were to..

Published: 20 Jun 2025

Quantum-Safe Networks for 6G: An Integrated Survey on PQC, QKD, and Satellite QKD with Future Perspectives

Volume 2

Quantum computing poses significant challenges to the current cryptographic landscape, particularly with the upcoming deployment of 6G networks. Traditional cryptographic algorithms, such as Rivest-Shamir-Adleman (RSA) and Elliptic Curve Cryptography (ECC), are vulnerable to quantum-based attacks. This vulnerability has led to the development of Post-Quantum Cryptography (PQC), Quantum Key Distribution (QKD), and Satellite-based QKD solutions. This paper provides a comprehensive review of these quantum-safe technologies, discussing their integration within the context..

Published: 25 Jun 2025

Political Instability and the Treadmill of Production: Sustainable Urban Processes in Kabul City

Volume 1

Political instability and weak institutional governance have exacerbated environmental degradation in Kabul City, where the relentless treadmill of production continues to strain natural resources. This study examines how weak institutional governance, conflict, corruption, and economic pressures contribute to unsustainable environmental practices, intensifying pollution, deforestation, and resource depletion. As political instability weakens institutional capacities, regulatory enforcement diminishes, allowing industrial and urban expansion to proceed unchecked. The treadmill of production, driven by..

Published: 26 May 2025

A Review on the Cell-Penetrating Peptides

Volume 1

The therapeutic potential of biomacromolecules in treating various diseases is undeniable; however, their application is significantly limited by the inherent barrier function of the cell membrane. Cell-penetrating peptides (CPPs), a class of small peptides comprising fewer than 30 amino acids, have garnered considerable attention due to their exceptional ability to traverse cell membranes. These peptides ease the intracellular delivery of various macromolecules, such as proteins, polypeptides, and nucleic acids, thereby..

Published: 12 May 2025

Artificial Intelligence at the Crossroads of Engineering and Innovation

Volume 2

The field of Artificial Intelligence (AI) is progressively transforming various advanced engineering disciplines, including mechanical, civil, electrical, aerospace, environmental, and biomedical engineering, through improved design, manufacturing, maintenance, and optimization methodologies. Yet, the disjointed and specialized state of the art too frequently prevents the cross-disciplinary application of AI solutions due to disparate performance measures, which result in reduced knowledge transfer and exaggerated performance in segregated domains. This study overcomes these issues..

Published: 07 May 2025

Exploring Artesunate and Dihydroartemisinin for Mechanism on MMP-3 and MMP-13 via Molecular Docking and Molecular Dynamics

Volume 2

The application of natural products has drawn increasing attention in recent times. Artesunate (ART) and Dihydroartemisinin (DHA), being natural products with anti-inflammatory and cartilage protective capabilities, have shown potential in osteoarthritis (OA) treatment. OA is a highly prevalent degenerative joint disease globally, leading to a diminished quality of life and is a major cause of disability. Matrix metalloproteinase 3 (MMP-3) and MMP-13 play crucial roles in OA progression. Although ART..

Published: 28 Apr 2025

Synergistic Modulation of ER Stress and Insulin Potentiation Therapy for Enhanced Cancer Treatment

Volume 1

Cancer cells sustain rapid growth by reprogramming their metabolism to depend heavily on glycolysis, enhanced insulin signaling, and adaptive changes in the unfolded protein response (UPR). Insulin Potentiation Therapy (IPT) enhances the efficacy of chemotherapy by increasing insulin receptor expression, thereby improving the uptake of chemotherapeutic agents. Meanwhile, targeting endoplasmic reticulum (ER) stress disrupts the protein-folding machinery within cancer cells, steering them toward apoptosis. However, IPT faces several limitations, including..

Published: 30 Jun 2025

Effect of Acyl Chain Variation and Cholesterol on Structural and Dynamic Properties of Lipid Bilayer Probed by Simulation

Volume 2

Lipid ordering plays a crucial role in maintaining the mechanical strength of the lipid bilayer, which is influential in controlling biological functions. This is associated with the well-known phenomena of “phase state behavior” of the bilayer. The significant factors that influence phase state behavior are stimuli such as cholesterol, physiological conditions like temperature and pH, and the structure of the lipid molecule itself, which can differ either in the head..

Published: 06 May 2025

Comprehensive Classification of Web Tracking Systems: Technological Insights and Analysis

Volume 2

Web tracking (WT) systems are advanced technologies that are used to monitor and analyze online user behavior. Initially focused on HTML and static webpages, these systems have evolved with the proliferation of IoT, edge computing, and Big Data, encompassing a broad array of interconnected devices with APIs, interfaces, and computing nodes for interaction. WT systems are pivotal in technological innovation and business development, although trends like GDPR complicate data extraction..

Published: 07 May 2025

A Novel Transformer Reinforcement Learning-Based NFV Service Placement in MEC Networks

Volume 2

The advent of 5G networks has facilitated various Industry 4.0 applications requiring stringent Quality-of-Service (QoS) demands, notably Ultra-Reliable Low-Latency Communication (URLLC). Multi-Access Edge Computing (MEC) has emerged as a key technology to support these URLLC applications by bringing computational resources closer to the user, thus reducing latency. Meanwhile, Network Function Virtualization (NFV) supports 5G networks by offering flexibility and scalability in service provisioning across various applications. Despite their benefits, MEC..

Published: 21 Apr 2025

Identification of Hub Genes and Molecular Mechanisms of Association of PCOS, Breast, and Ovarian Cancers Using an Integrated Bioinformatics Analysis

Volume 2

Background: Oxidative stress plays a crucial role in various aspects of cancer and other diseases. While reactive oxygen species (ROS) serve as key signal molecules in physiological processes for the normal functioning of the female reproductive system, they have also been implicated in pathological processes such as polycystic ovary syndrome (PCOS). Some studies have reported a significantly higher risk of endometrial cancer in women with PCOS. However, the association of..

Published: 21 Mar 2025

Characteristics of Tumor Infiltrating Lymphocytes in Patients with Benign and Malignant Sinonasal Neoplasms

Volume 1

Introduction. Tumor infiltrating lymphocytes are a major component of sinonasal neoplasms, actively populating tumor tissue, yet their role remains poorly understood. The aim is to characterize subsets and functional profiles of tumor infiltrating lymphocytes in patients with benign and malignant sinonasal tumors. Materials and methods. Tumor infiltrating lymphocytes were isolated from the biopsy material of 58 patients: 18 with sinonasal malignancies, 23 with inverted papilloma and 17 with polypous rhinosinusitis..

Published: 07 Mar 2025

Clinical Pharmacy at the Crossroads: Advancing Care, Improving Outcomes

Volume 1

Clinical pharmacy has evolved from a field that focuses on the dispensing and distribution of medications to a modern, colossal field that is imperative to the patient-driven care [1,2]. Clinical pharmacists play a multifaceted and crucial role in patient care via integrating knowledge and skills into clinical practice, thereby contributing to improved health outcomes. Specifically, they design tailored pharmacotherapy that matches patients’ needs, with a focus on ensuring medication safety..

Published: 20 Mar 2025

Unusual Arrangement of Catalytic Loops of the Alcohol Dehydrogenase Enzyme During the Adsorption Process on a Graphitic Carbon Surface

Volume 2

Molecular dynamics simulations (MDs) were conducted to investigate the alcohol dehydrogenase (ADH) enzyme and its cofactor, nicotinamide adenine dinucleotide (NAD), solvated in an aqueous system on a graphite-carbon surface. The study focuses on key structural aspects of ADH, particularly its conformational changes, including the rotation of the catalytic domain, the coenzyme binding domain, and the rearrangement of the active center required for catalytic activation. MDs were performed for 100 ns..

Published: 19 Mar 2025

Soluble Biomarkers as Predictors of Response to Immunotherapy in Non-Small Cell Lung Cancer (NSCLC)-Insights from the Tumor Microenvironment Perspective

Volume 1

Lung cancer is the major cause of mortality worldwide with non-small cell lung cancer (NSCLC) contributing to 85% of the cases. FDA-approved immune checkpoint inhibitors (ICI), anti-PD-1, and anti-PD-L1 are widely used as a standard treatment. However, the response rate is limited and is observed in only 20–40% of the patients. Therefore, predictive and prognostic biomarkers are needed to help differentiate responders from non-responders, enabling a better understanding of disease..

Published: 21 Mar 2025

Epidemiological Investigation and Assessment of HEVs in Shellfish Based on Meta-Analysis

Volume 1

Hepatitis E virus (HEV) is an acute zoonotic infectious disease that can cause hepatitis E and may even lead to death in severe cases. Porcine organisms are regarded as the natural hosts carrying hepatitis E virus, and it is also commonly found in other products. Meanwhile, shellfish are also one of the main hosts. The aim of this study was to estimate the global prevalence of hepatitis E virus in..

Published: 11 Feb 2025

CRISPR-Cas9 is Revolutionizing AML Treatment as a Novel Therapy

Volume 1

This review explores the progression of CRISPR-Cas9 genome editing technology in gene therapy for acute myeloid leukemia. Acute Myeloid Leukemia, a serious blood cancer, presents formidable treatment obstacles and a dismal prognosis. Effective treatments for acute myeloid leukemia rely on a clear understanding of its intricate genetic mechanisms, and CRISPR-Cas9 technology offers precision and adaptability for targeting the disease’s oncogenic drivers. The dual intron-targeting method of CRISPR-Cas9 is showcased in..

Published: 21 Mar 2025

Traditional Strategies and Cutting-Edge Technologies Used for Animal Breeding: A Comprehensive Review

Volume 1

Food security continues to remain a critical challenge confronting humanity. Worldwide, the demand for food products is extensively increasing. Today, the research of generating transgenic organisms is one of the fastest-developing biotechnology fields, as it promises sustainability of agriculture and aquaculture. Many of the animals observed today, including top-quality agricultural breeds such as Holstein cows and Landrace swine, have undergone significant changes and are entirely distinct from their wild ancestors...

Published: 20 Mar 2025

Prediction of Cognitive Impairment Using a Deep Learning Autoencoder Algorithm from a Singapore Study

Volume 2

Dementia is a decline in cognitive function, typically diagnosed when the acquired impairment becomes severe enough to impact social or occupational functioning. Between no cognitive impairment (NCI) and dementia, there are many intermediate states. Predictive cognitive impairment can be useful for initiating treatment to prevent further brain damage. Several deep learning-based approaches have been proposed for the classification of Magnetic Resonance Imaging (MRI) to diagnose Alzheimer’s disease (AD) or dementia...

Published: 28 Feb 2025

A Mini Review on Used Medical Yarns in the Braiding Production Methods for Biomaterial Applications

Volume 2

Biomaterials are advanced materials that can be implanted within the body, depending on the required design criteria, usually as a result of the production of polymeric-based, and medical yarns by the braiding method. Braiding method is widely used in the production of biomaterials due to its advantages, including a high elastic modulus, high tensile strength, and high dimensional stability properties. The high biological and mechanical properties required in biomaterials depend..

Published: 10 Mar 2025

A Novel Approach towards Establishing Free Space Optical Inter Satellite Links beyond the Kármán Line

Volume 1

The rapid surge in the technological advancement of humanity calls for development of faster, reliable & effective communication methods between satellites orbiting in outer space. The infamous inter-satellite link technology, coupled with free space optical communication is a robust solution for the same. While establishing this for low earth orbit satellites, it is critical to ensure that the links established across the two satellites avoid the atmosphere, i.e., the links..

Published: 28 Feb 2025

Precision Medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-Based Therapies, Challenges and Perspectives

Volume 2

This manuscript examines advancements in antigen-specific immunosuppression, as well as the potential and challenges of applying gene-editing technologies to autoimmune diseases driven by autoantibodies (AAbs). Current approved treatments fail to reach long-lived plasma cells (LLPCs), which may continue secreting pathogenic AAbs after immunobiological courses in some autoimmune illnesses. New approaches, some tested in vitro and some already undergoing clinical trials, such as the chimeric autoantibody receptor (CAAR)-T cells, BiTEs, affinity..

Published: 18 Mar 2025

Physical Layer Security in Lossy Untrusted Relay Networks with Finite Blocklength

Volume 1

In this paper, we examine the physical layer security (PLS) in lossy untrusted relay networks, focusing on finite blocklength transmissions. In such networks, ensuring secure communication is particularly challenging due to the presence of untrusted relay nodes and the inherent limitations of short-packet transmissions. We propose the reliable-and-secure probability (RSP) as a performance metric to evaluate the likelihood that the destination node successfully recovers the transmitted message while untrusted relays..

Published: 15 Jan 2025

The Potential of Artificial Intelligence and Machine Learning in Pharmacovigilance: An Update

Volume 2

The integration of artificial intelligence (AI) and machine learning (ML) into pharmacovigilance (PV) marks a transformative step towards enhancing drug safety and patient outcomes. With their unparalleled ability to analyze vast and complex datasets, AI/ML technologies offer unprecedented opportunities to revolutionize adverse drug event (ADE) monitoring, signal detection, and causality assessment. This editorial explores the state-of-the-art applications, key challenges, and actionable strategies to unlock the full potential of AI in..

Published: 31 Dec 2024

Preface

Volume 1

Welcome to the inaugural volume of the Computing & AI Connect (CAIC) Journal, a peer-reviewed, open-access journal committed to fostering advancements and innovation in computing sciences and technologies, and artificial intelligence. CAIC is a platform that is dedicated to exploring the profound and transformative impacts of computing and artificial intelligence on the different aspects of life. In recent years, AI has become the focus of researchers from different fields, working to..

Published: 08 Jan 2025

Chronic Myelomonocytic Leukemia Relapse After Transplant

Volume 1

Relapse of Chronic Myelomonocytic Leukemia after allogeneic hematopoietic stem cell transplantation remains a significant challenge, with relapse rates reaching up to 50%, contributing to poor survival outcomes. This paper explores the factors influencing relapse, including disease biology and persistence of residual disease. Current, post- transplant strategies, such as maintenance therapies and immunomodulatory treatments, are discussed for their potential to reduce the likelihood of relapse. It also highlights emerging therapies, such..

Published: 04 Apr 2025

Smart Gas Sensing by (Al/C/Si)-Doped Boron Nitride Nanomaterial Towards Grabbing Nitric Oxide: A Novel Applied Technique for Air Pollution Reduction by DFT Analysis

Volume 2

The electronic, magnetic, and thermodynamic properties of adsorption of toxic gases, including Nitric oxide (NO) by using Y (Y = Al, C, Si)-doped boron nitride nanocage (BN) have been investigated using density functional theory (DFT). The results denote that NO→Y–BN are stable compounds, with the most stable adsorption site being the center of the cage ring. Furthermore, the reported results of nuclear magnetic resonance (NMR) spectroscopy have exhibited the strength..

Published: 26 Dec 2024

Study of the 3-(3,3-Dimethylbutanoyl)-4-hydroxy-6-neopentyl-2H-pyran-2-one by IR, Raman spectroscopy, and DFT

Volume 1

The heterocyclic structure of pyrones has a variety of biological activities and plays an important role in the creation of new drugs. Therefore, the study of the structure and spectra of pyrones is of considerable interest. In this work, the IR and Raman spectra of 3-(3,3-Dimethylbutanoyl)-4-hydroxy-6-neopentyl-2H-pyran-2-one (1) in its crystalline state was studied. The tautomerization of 1 was followed by a quantum-chemical method at the DFT/B3LYP/6-311G** level. The calculation for..

Published: 07 Feb 2025

A Systematic Review on the Integrating Artificial Intelligence for Enhanced Fault Detection in Power Transmission Systems: A Smart Grid Approach

Volume 2

Modern electrical systems rely on sensors and relays for fault detection in three-phase transmission lines and distribution transformers, but these devices often face time complexity issues and false alarms. In this study, the fault detection accuracy is compared in models studied in 2023 and 2024 following PRISMA guidelines. The objectives were to identify fault types, utilize machine learning models to assess their predictive efficacy, and establish accuracy levels. To explore..

Published: 28 Nov 2024

Preface

Volume 1

It is both an honor and a privilege to introduce this inaugural issue of Biomaterials Connect. Biomaterials Connect is a newly established journal that intends to be an inclusive forum for all researchers, scientists, engineers, and professionals working within the various fields of biomaterials science. The purpose is to encourage the contribution to multi-disciplinary interaction, the diffusion of new ideas, and contributing to biomaterials research and applications, but in particular..

Published: 29 Nov 2024

Epidermolytic Hyperkeratosis Type 1 with a New Heterozygous Mutation in KRT1 Gene: A Case Report

Volume 1

Background: Epidermolytic hyperkeratosis (EHK) formerly known as bullous ichthyosiform erythroderma, is a rare autosomal dominant inheritance condition with a prevalence ranging from 1:200,000 to 1:300,000. The underlying etiology of which is a mutation in the genes responsible for keratin proteins synthesis, primarily in KRT1 and KRT10 genes, cataloged under OMIM number 113800. The clinicopathological presentations include blistering during the neonatal period, followed by ichthyotic hyperkeratosis in childhood and adolescence. This..

Published: 20 Nov 2024

Impact of Surface Modification of Hemp Fibers Using a Coupling Agent in Solvent on the Properties of Polyethylene Composites

Volume 1

This study investigates the grafting of a coupling agent, maleic anhydride-grafted polyethylene (MAPE), onto hemp fibers in a 1,2,4-trichlorobenzene (TCB) solution, followed by an evaluation of the morphological, rheological, and mechanical properties of the resulting polyethylene composites containing 30% hemp. SEM analysis revealed the formation of a thin layer of MAPE on the surface of the modified fibers. This was further confirmed by the appearance of a MAPE degradation peak..

Published: 18 Nov 2024

Biofunctional Applications of Chitosan in Dentistry - An Overview

Volume 1

Chitosan, with its unique properties, has garnered the interest of materials scientists worldwide, leading to exploration in bio-dental applications. In dentistry, chitosan has shown a wide range of applications. The creation of effective biomaterials for the prevention and treatment of dental disorders is a challenge for researchers in the present scenario. The natural semi-synthetic polysaccharide-based biomaterial Chitosan is derived from chitin, which is sourced from marine organisms. Due to its..

Published: 05 Nov 2024

Evaluation of IL 12 Gene Expression and Serum Levels of OxPL / apoB in Patients with Coronary Artery Disease

Volume 1

Background Atherosclerotic lesions are formed as a result of low-density lipoprotein (LDL) accumulation, which is produced by oxidizing enzymes and oxidized phospholipids (OxPL). Phospholipid oxide causes inflammation-inducing activation genes and hyper-inflammation in addition to the initiation of inflammation and expression of Th1 cytokines. Interleukin 12 (IL-12) is one of the most significant stimulants of inflammation and immune responses, among the Th1cytokines. Therefore, it may play a significant role in contributing..

Published: 24 Oct 2024

Preparation and Characterization of Acetate Cellulose Laurate Ester in Sodium Acetate/Zinc Chloride Systems

Volume 1

The objective of this study was to explore the preparation and characterization of acetate cellulose laurate ester in sodium acetate/zinc chloride systems. The cellulose used in the study was obtained from oil palm empty fruit bunch and oil palm frond. The characterization of both the isolated cellulose and the acetate cellulose laurate ester was carried out using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Differential thermogravimetric (DTG), and Thermogravimetric..

Published: 11 Oct 2024

Exploring a New Era in Cell Engineering

Volume 1

As the Editor-in-Chief of Cell Engineering Connect, it is both an honor and a privilege to introduce this inaugural issue. Our journal is dedicated to exploring the latest advancements in the rapidly evolving field of cell engineering, an interdisciplinary domain that holds the key to transformative innovations in healthcare, biotechnology, and synthetic biology. The convergence of cell biology, bioengineering, and data science is enabling researchers to manipulate cellular systems in..

Published: 28 Sep 2024

Towards Low Complexity VLC Systems: A Multi-Task Learning Approach

Volume 1

In the rapidly evolving landscape of wireless communication, visible light communication (VLC) stands out for its potential to redefine high-speed data exchange. Recently, VLC has utilized waveforms that combine multiple bitstreams in a unified physical layer, allowing for high-speed data exchange, precise localization, and robust control simultaneously. Particularly, the demodulation tasks of beacon position modulation (BPM) and beacon phase shift keying (BePSK) are central to decoding of such waveforms and..

Published: 17 Oct 2024

Investigation of TLR4, TLR6, TLR7, and CD36 Expression on T lymphocytes in Coronary Artery Disease

Volume 1

Background: Coronary artery disease (CAD) is among the significant causes of death globally, caused by fatty deposits in blood vessel walls. Increasing evidence indicates that toll-like receptors (TLRs) are pivotal to atherosclerosis progression. The function of CD36 as a glycoprotein in atherosclerosis was also suggested. This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD. Methods: This study included..

Published: 10 Sep 2024

3D Printing of Biomaterials: Is It Disruptive or Destructive?

Volume 1

3D printing represents a new era in the field of digital manufacturing, finding its applications in many industries, such as healthcare, automotive, and aerospace. In particular, 3D printing has the potential to completely revolutionize the manufacturing process for implants, medical equipment, and even human tissues within the healthcare industry. The rapid rise of 3D printing raises fundamental questions i.e., Is this technology truly revolutionary, or does it perhaps take us..

Published: 10 Sep 2024

Diversity of HLA Class I and II Genes in the North Indian Population

Volume 1

Introduction: Numerous studies have concentrated on specific populations to explore the extensive polymorphism of class I and II HLA genes. This genetic diversity is crucial for various applications, such as advancing transplantation immunology, understanding genetic population patterns, and uncovering the pathways of different diseases. Objective: The objective of the present study was to determine and analyse the frequencies of class I (HLA-A, HLA-B and, HLA-C), and class II (HLA-DRB1, and..

Published: 29 Aug 2024

Ethical Approaches in Secondary Findings Report from Exome Sequencing Analysis

Volume 1

In Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) approaches, incidental findings (IFs) or more precisely secondary findings (SFs) have indicated controversial reports. To address SFs issues, well-known guidelines have been released such as the versions of the American College of Medical Genetics and Genomics (ACMG); however, when, to whom, why, and how these SFs should be reported are the key questions that need to be addressed ethically. The..

Published: 23 Aug 2024

The Secret Life of Microbes: The Expanding Role of Microbes in Shaping Endocrine Health—The Role of Microbes in Endocrinology Health

Volume 1

This review was intended to attempt to establish the complex association between the endocrine system of the host and the gut microbiota. Microbial endocrinology is a relatively new field of study, which examines how microbes regulate hormonal; and affect metabolisms, immune system, and behavior responses. This is because the gut microbiome can be viewed as a virtual endocrine organ as it is involved in the synthesis of neuroactive substances as..

Published: 28 Aug 2024

An Overview of Secure Network Segmentation in Connected IIoT Environments

Volume 1

Network segmentation is a very important approach in enhancing network security. The approach involves breaking down the network into smaller, more manageable segments, each with its own specific security requirements. This strategy supports maintaining stable perimeters and effective access control while safeguarding critical resources, such as database servers, from unauthorized access. The relevance of network segmentation in IIoT comes with the state-of-the-art and interconnected nature of many devices that may..

Published: 02 Aug 2024

Challenging Conventions Towards Reliable Robot Navigation Using Deep Reinforcement Learning

Volume 1