GenoMed Connect

Metabolic Reprogramming in Brain Metastases: Integrating Spatial Omics with Non-Spatial Mechanistic Evidence

Vol. 3

Brain metastases (BrMs) develop within a metabolically specialized environment, where nutrient availability and interactions with neural, vascular and immune cells can influence tumor growth. Bulk and single-cell studies...

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Noncoding RNA-Mediated Control of HbF Switching: From Molecular Mechanisms to Clinical Translation

Vol. 3

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July 9, 2026

Unveiling the Fourth Meningeal Layer: Implications for Brain Structure, Function, and Neurological Disease

Vol. 3

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July 8, 2026

Dynamic Virtual Tumor Cells Powered by Spatial Omics for Translational Oncology

Vol. 3

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June 12, 2026

Spatial Profiling of the Head and Neck Squamous Cell Carcinoma Microenvironment: Reshaping Our Understanding and Therapeutic Opportunities

Vol. 3

Head and neck squamous cell carcinoma (HNSCC) is characterized by a highly heterogeneous tumor microenvironment (TME), which plays a critical role in disease progression and therapeutic resistance. The emergence of spati...

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June 11, 2026

Regional Differences in Brain Tumors: Genetic Drivers and Spatial Molecular Ecology

Vol. 3

The human brain exhibits marked regional specialization in cellular composition, gene expression, and tissue architecture. Growing evidence suggests that these spatial differences influence both the anatomical distributi...

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June 5, 2026

Spatial Heterogeneity of TMEs in cHL and PDAC: Mechanistic Insights and Therapeutic Perspectives

Vol. 3

The tumor microenvironment (TME) is a critical niche that influences tumor progression and the development of therapeutic resistance. Spatial omics technologies enable in situ investigation of cellular ecology and interc...

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May 25, 2026

Y-STR Mutation Patterns in North Indian Male Relatives at 16 Loci: A Preliminary Study

Vol. 3

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December 31, 2025

Origin, Evolution, and Regulation of Cancer Genes: An Overview

Vol. 2

Cancer is characterized by abnormal cell proliferation in multicellular organisms. Its emergence is linked to the evolution of multicellularity billions of years ago. The “incipient cancer genes” (proto-oncogenes) presum...

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December 30, 2025

Spatial Omics in Decoding Oral Squamous Cell Carcinoma Heterogeneity: Microenvironment Crosstalk and Multi-Omics Integration

Vol. 2

Oral squamous cell carcinoma (OSCC) is a significant concern within head and neck cancers due to its high heterogeneity, which contributes to poor treatment outcomes and low survival rates in advanced stages. This review...

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December 29, 2025

A Century of Alkaptonuria: Evolving Insights into a Rare Metabolic Disorder

Vol. 2

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December 27, 2025

Effect of Conjugated siRNA-Gold Nanoparticles on Antibiotic-Resistance Integron Class I Gene

Vol. 2

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December 18, 2025

AI-Driven Machine Learning Analysis in Major Depressive Disorder (MDD): Sex-Based Variations in Oxytocin and Clinical Profiles

Vol. 2

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October 3, 2025

Current Insights into Pharmacogenomics of Noncoding RNAs for Cancer Therapy

Vol. 2

Cancer remains a significant global health challenge, with varying incidence and mortality rates across the globe. According to the Surveillance, Epidemiology, and End Results (SEER) registry [1] and the American Cancer...

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June 24, 2025

Epigenetic Insights into Bladder Cancer: The Role of Urine DNA Methylation Assays: Mini Review

Vol. 2

Bladder cancer remains a major global health challenge due to its high incidence, recurrence rates, and reliance on invasive diagnostic procedures. While conventional methods, such as cystoscopy and urine cytology, are c...

1 citation

June 23, 2025

Clinical Diversity and Outcomes of Progressive Familial Intrahepatic Cholestasis Diagnosed by Whole Genome Sequencing in Pakistani Children

Vol. 2

Progressive familial intrahepatic cholestasis (PFIC) is a rare group of genetic disorders that typically presents in infants and children, often progressing to end-stage liver disease. We used whole genome sequencing (WG...

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April 21, 2025

Identification of Hub Genes and Molecular Mechanisms of Association of PCOS, Breast, and Ovarian Cancers Using an Integrated Bioinformatics Analysis

Vol. 2

Background: Oxidative stress plays a crucial role in various aspects of cancer and other diseases. While reactive oxygen species (ROS) serve as key signal molecules in physiological processes for the normal functioning o...

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February 28, 2025

Precision Medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-Based Therapies, Challenges and Perspectives

Vol. 2

This manuscript examines advancements in antigen-specific immunosuppression, as well as the potential and challenges of applying gene-editing technologies to autoimmune diseases driven by autoantibodies (AAbs). Current a...

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