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GenoMed Connect

ISSN: 3006-9033
 
 

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Articles

 
Review

Published: 23 Aug 2024

The Secret Life of Microbes: The Expanding Role of Microbes in Shaping Endocrine Health

Volume 1

Abstract

This review was intended to attempt to establish the complex association between the endocrine system of the host and the gut microbiota. Microbial endocrinology is a relatively new field of study, which examines how microbes regulate hormonal signaling and affect metabolisms, immune system, and behavior responses. This is because the gut microbiome can be viewed as a virtual endocrine organ as it is involved in the synthesis of neuroactive substances..

https://doi.org/10.69709/GenomC.2024.193113
Review

Published: 29 Aug 2024

Ethical Approaches in Secondary Findings Report from Exome Sequencing Analysis

Volume 1

Abstract

In Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) approaches, incidental findings (IFs) or more precisely secondary findings (SFs) have indicated controversial reports. To address SFs issues, well-known guidelines have been released such as the versions of the American College of Medical Genetics and Genomics (ACMG); however, when, to whom, why, and how these SFs should be reported are the key questions that need to be addressed ethically. The..

https://doi.org/10.69709/GenomC.2024.197183
Article

Published: 09 Sep 2024

Diversity of HLA Class I and II Genes in the North Indian Population

Volume 1

Abstract

Introduction: Numerous studies have concentrated on specific populations to explore the extensive polymorphism of class I and II HLA genes. This genetic diversity is crucial for various applications, such as advancing transplantation immunology, understanding genetic population patterns, and uncovering the pathways of different diseases. Objective: The objective of the present study was to determine and analyse the frequencies of class I (HLA-A, HLA-B and, HLA-C), and class II (HLA-DRB1, and..

https://doi.org/10.69709/GenomC.2024.193514
Article

Published: 10 Sep 2024

Investigation of TLR4, TLR6, TLR7, and CD36 expression on T lymphocytes in coronary artery disease

Volume 1

Abstract

Background: Coronary artery disease (CAD) is among the significant causes of death globally, caused by fatty deposits in blood vessel walls. Increasing evidence indicates that toll-like receptors (TLRs) are pivotal to atherosclerosis progression. The function of CD36 as a glycoprotein in atherosclerosis was also suggested. This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD. Methods: This study included..

https://doi.org/10.69709/GenomC.2024.197851
Article

Published: 23 Sep 2024

Identification of prognostic biomarkers and tumor immune microenvironment about Uveal melanoma

Volume 1

Abstract

Uveal melanoma (UM) is a malignant eye cancer that has a high mortality rate and is notoriously difficult to diagnose clinically. Identifying prognostic biomarkers and evaluating the tumor immune microenvironment for UM in order to improve diagnosis, treatment decisions and even overall survival for patients. Our study involved a thorough analysis of the transcriptome profiling in the TCGA-UVM project with the aim of identifying biomarkers as well as exploring the..

https://doi.org/10.69709/GenomC.2024.196011
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