GenoMed Connect

December 31, 2025

Origin, Evolution, and Regulation of Cancer Genes: An Overview

Vol. 2

Cancer is characterized by abnormal cell proliferation in multicellular organisms. Its emergence is linked to the evolution of multicellularity billions of years ago. The “incipient cancer genes” (proto-oncogenes) presum...

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December 30, 2025

Spatial Omics in Decoding Oral Squamous Cell Carcinoma Heterogeneity: Microenvironment Crosstalk and Multi-Omics Integration

Vol. 2

Oral squamous cell carcinoma (OSCC) is a significant concern within head and neck cancers due to its high heterogeneity, which contributes to poor treatment outcomes and low survival rates in advanced stages. This review...

1 citation

December 29, 2025

A Century of Alkaptonuria: Evolving Insights into a Rare Metabolic Disorder

Vol. 2

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December 27, 2025

Effect of Conjugated siRNA-Gold Nanoparticles on Antibiotic-Resistance Integron Class I Gene

Vol. 2

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December 18, 2025

AI-Driven Machine Learning Analysis in Major Depressive Disorder (MDD): Sex-Based Variations in Oxytocin and Clinical Profiles

Vol. 2

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October 3, 2025

Current Insights into Pharmacogenomics of Noncoding RNAs for Cancer Therapy

Vol. 2

Cancer remains a significant global health challenge, with varying incidence and mortality rates across the globe. According to the Surveillance, Epidemiology, and End Results (SEER) registry [1] and the American Cancer...

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June 24, 2025

Epigenetic Insights into Bladder Cancer: The Role of Urine DNA Methylation Assays: Mini Review

Vol. 2

Bladder cancer remains a major global health challenge due to its high incidence, recurrence rates, and reliance on invasive diagnostic procedures. While conventional methods, such as cystoscopy and urine cytology, are c...

1 citation

June 23, 2025

Clinical Diversity and Outcomes of Progressive Familial Intrahepatic Cholestasis Diagnosed by Whole Genome Sequencing in Pakistani Children

Vol. 2

Progressive familial intrahepatic cholestasis (PFIC) is a rare group of genetic disorders that typically presents in infants and children, often progressing to end-stage liver disease. We used whole genome sequencing (WG...

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April 21, 2025

Identification of Hub Genes and Molecular Mechanisms of Association of PCOS, Breast, and Ovarian Cancers Using an Integrated Bioinformatics Analysis

Vol. 2

Background: Oxidative stress plays a crucial role in various aspects of cancer and other diseases. While reactive oxygen species (ROS) serve as key signal molecules in physiological processes for the normal functioning o...

1 citation

February 28, 2025

Precision Medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-Based Therapies, Challenges and Perspectives

Vol. 2

This manuscript examines advancements in antigen-specific immunosuppression, as well as the potential and challenges of applying gene-editing technologies to autoimmune diseases driven by autoantibodies (AAbs). Current a...

1 citation

January 15, 2025

The Potential of Artificial Intelligence and Machine Learning in Pharmacovigilance: An Update

Vol. 2

The integration of artificial intelligence (AI) and machine learning (ML) into pharmacovigilance (PV) marks a transformative step towards enhancing drug safety and patient outcomes. With their unparalleled ability to ana...

4 citations

January 9, 2025

How Caffeine Affects Alpha-Amylase: An In Vivo Study

Vol. 2

Background: Caffeine is a widely consumed psychostimulant with various effects, including weight and metabolic parameters. Caffeine consumption has been associated with increased blood glucose levels and reduced insulin...

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December 12, 2024

The Placement of Auer Rods as a Single Diagnostic Criterion for the Highest-Risk Category of Myelodysplastic Syndromes: A Single-Institution Study and Critical Analysis

Vol. 2

Accurate determination of prognostic risk is critical for patients and treating clinicians. The French-American-British classification of myelodysplastic syndromes (MDS) described refractory anemia with excess blasts (RA...

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