Available Online: 30 Dec 2025
Spatial Omics in Decoding Oral Squamous Cell Carcinoma Heterogeneity: Microenvironment Crosstalk and Multi-Omics Integration
This article is part of the Special Issue Spatial Omics in Cancer: Decoding Heterogeneity, Microenvironment Crosstalk, and Therapeutic Implications
Volume 2
-
Xiaotong You
xiaotongyou@connect.hku.hk
-
Yu Liu
yuliu23@connect.hku.hk
Oral squamous cell carcinoma (OSCC) is a major issue in the sphere of head and neck cancer since it is very heterogeneous, which also leads to the poor treatment results and low survival rates in the advanced stages. Here, the review will discuss how spatial omics methods explore tumor heterogeneity in OSCC, which includes cellular, molecular, and immune microenvironment alterations that occur due to cancer stem cells, stromal interactions, genetic..