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Articles (2)

Editorial

Published: 03 Oct 2025

Current Insights into Pharmacogenomics of Noncoding RNAs for Cancer Therapy

Volume 2

Cancer remains a significant global health challenge, with varying incidence and mortality rates across the globe. According to the Surveillance, Epidemiology, and End Results (SEER) registry [1] and the American Cancer Society (ACS) [2], more than 2 million new cancer cases are expected in the US by 2025. Understanding the burden of disease and advancements in tailored treatments, also known as precision or personalized medicine, is crucial for improving patient..

Journal: GenoMed Connect
Review Article

Published: 28 Apr 2025

Synergistic Modulation of ER Stress and Insulin Potentiation Therapy for Enhanced Cancer Treatment

Volume 1

Cancer cells sustain rapid growth by reprogramming their metabolism to depend heavily on glycolysis, enhanced insulin signaling, and adaptive changes in the unfolded protein response (UPR). Insulin Potentiation Therapy (IPT) enhances the efficacy of chemotherapy by increasing insulin receptor expression, thereby improving the uptake of chemotherapeutic agents. Meanwhile, targeting endoplasmic reticulum (ER) stress disrupts the protein-folding machinery within cancer cells, steering them toward apoptosis. However, IPT faces several limitations, including..

Journal: Cell Therapy & Engineering Connect
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