Organic & Medicinal Chemistry Connect is a peer-reviewed open access journal devoted to publishing cutting-edge research, perspectives, and short communications at the interface of organic synthesis, medicinal chemistry, and translational drug discovery. The journal provides a dynamic platform for scientists in academia, biotech, and pharmaceutical industries to disseminate transformative advances that drive innovation in the discovery of therapeutics addressing unmet medical needs.
The journal aims to:
- Bridge the disciplines of organic chemistry, chemical biology, and medicinal chemistry to accelerate the discovery of novel bioactive molecules.
- Promote innovation in drug design through the integration of synthetic chemistry, molecular modeling, chemoproteomics, and target-based pharmacology.
- Provide a forum for rapid communication of high-impact discoveries through research letters, communications, and perspectives.
- Highlight emerging concepts such as covalent inhibitors, mono- and bivalent molecular glues, and targeted protein degradation that redefine traditional drug discovery paradigms.
- Encourage interdisciplinary and translational research linking chemical innovation to biological function and therapeutic application.
The journal welcomes original research articles, review articles, short communications, and perspectives in the following areas included but not limited to:
Medicinal Chemistry
- Design, synthesis, and structure–activity relationship (SAR) studies of novel drug candidates
- Discovery of first-in-class and best-in-class therapeutics
- Covalent drugs, PROTACs, molecular glues (mono- and bivalent), and other degradation-based modalities
- Computational and AI-assisted drug design
- Pharmacokinetics, metabolism, and target engagement studies
Organic and Synthetic Chemistry
- Novel synthetic methodologies relevant to drug and probe development
- Green and sustainable chemistry innovations
- Catalytic, asymmetric, and diversity-oriented synthesis
- Total synthesis and semisynthesis of natural products and analogs
- Synthetic strategies enabling chemical biology and medicinal chemistry applications
Chemical Biology and Chemoproteomics
- Activity-based protein profiling (ABPP) and covalent ligand discovery
- Photoaffinity labeling and probe design for target identification
- Proteome-wide reactivity profiling and selectivity mapping
- Chemical tools for functional proteomics, transcriptomics, and biomarker discovery
Emerging Topics
- Mono- and bivalent molecular glues for induced proximity and protein homeostasis
- RNA-targeted small molecules
- Chemical immunology, neuroactive compounds, and women’s health therapeutics
- Peptide and macrocycle drug discovery
- DNA-encoded libraries and high-throughput screening technologies
