Abstract

Biomaterials play a pivotal role in advancing tissue engineering, offering significant potential in the field of 3D bioprinting and translational medicine. Their development has led to the creation of innovative solutions in medical devices, dental implants, and prosthetics, where they serve to restore function and enhance patient quality of life.The success of these biomaterials is mostly based on important characteristics that guarantee their safe integration with the body and promote tissue regeneration, such as biocompatibility, biodegradability, and biofunctionality. This review explores recent advancements in these areas, with particular focus on the role of nanotechnology in enhancing biomaterial properties. The biomaterials have opened many avenues  by improving  mechanical, biological and functional properties for targeted treatments, precision therapies, improved therapeutic effectiveness and better results. Additionally, the rise of 3D printing technologies has transformed the design and fabrication of biomaterials, enabling the production of customized implants and scaffolds with intricate geometries suited to individual patient needs. This review examines the current state of research, challenges faced in the field, and emerging trends in the integration of nanotechnology and additive manufacturing to push the boundaries of biomaterial applications in tissue engineering and regenerative medicine.